A critical
evaluation of Glucosamine-based Joint supplements
Researched and composed by Vic
Goyaram
Introduction
Glucosamine is a very
popular ingredient in supplements meant for patients of osteoarthritis as well
as people engaged in sports and physical exercise for the maintenance of
healthy joints and joint regeneration.
Most joint supplements are based on Glucosamine which is purported to
help to support the structure and function of joints because it is a substrate
for the biosynthesis of glycosaminoglycan (GAG), the building blocks of joints
(Fallon, 2001). Glucosamine exists under several forms in supplements, namely
Glucosamine hydrochloride, N-Acetylglucosamine and the most popular chemical
form Glucosamine sulphate. The latter form is the most studied scientifically.
Glucosamine by itself accounted for USD 720 million in terms of sales in 2005.
This article attempts to review key aspects of glucosamine supplementation,
including a discussion of the evidence for and against its effectiveness in
joint healing.
Glucosamine product
formulations and dosages
Most joint products
contain glucosamine either as Glucosamine sulphate by itself or with added
Chondroitin and MSM (Figure 1). However,
although these different forms of glucosamine may be chemically related the
effects may not be the same when taken as supplements for the purported
benefits. Sulphate is the form which has
been used in most scientific studies on Glucosamine. Additionally, some joint
product formulations will also include other ingredients like MSM, Bromelain
and Collagen (Figure 2) which may be involved in joint support. These products
may come in the form of tablets, capsules or powder although tablets remain the
most common formulation, from personal observation.
Figure 1: The most common glucosamine-based joint support product formulation containing MSM and Chondroitin |
Figure 2: Example of more advanced formulations containing
glucosamine and other ingredients. The effectiveness of such formulas will be subject of another article. |
The dosages vary from
product to product but most contain about 1500-2000mg Glucosamine per
recommended serving.
Dosage and precautions
Glucosamine is not recommended for children as it
is mainly used to treat OA (a condition that affects adults) and its safety for
children has not been studied. The recommended dosage for adults is 500 mg, 3
times daily, for 30 - 90 days. Once daily dosing as 1.5 g (1,500 mg) may also
be used.
Most studies show that glucosamine needs to be
taken for 2 - 4 months before it is effective, although you may experience some
improvement sooner. Glucosamine and chondroitin can be used along with
nonsteroidal anti-inflammatory drugs (NSAIDs) to treat OA. Glucosamine must not
be administered haphazardly because it can have interaction with or counteract
the effect of some medications like Warfarin (Glucosamine may increase the
blood thinning effect of warfarin), Nonsteroidal anti-inflammatory drugs
(NSAIDs) (Glucosamine may reduce the need for NSAIDs), blood sugar lowering
medications or insulin (Glucosamine may change the dose needed for blood sugar
lowering medications and insulin).
Therefore it is always best to obtain medical clearance before
commencing glucosamine treatment in the presence of existing medical conditions
that necessitate the use of the above drugs.
Evaluating the evidence for the effectiveness of Glucosamine
The use of glucosamine is common among athletes at
all ages and levels (Buckwalter 2003) but here is little if any evidence
currently available about the claimed anti-inflammatory, analgesic, or
protective effects of glucosamine in the athletic environment. One study by Ostojica et al. (2007) studied the
effect of 4 weeks of glucosamine administration (1500 mg per day) on the
functional ability and the degree of pain intensity in competitive male
athletes who had acute knee injury. No
significant difference was seen in pain intensity and knee swelling between the
glucosamine and placebo group. However,
improvements in knee flexion and extension were noted thereby indicating that
glucosamine may have an effect on joint mobility in injured states.
Glucosamine has been studied in cases of osteoarthritis
(OA). Osteoarthritis is a type of arthritis that occurs when cartilage breaks
down and is lost, either due to injury or to normal wear and tear. It commonly
occurs with age. In some studies, glucosamine supplements have:
(a) decreased
the joint pain of OA,
(b) improved function in people with hip or knee OA,
(c) reduced joint swelling and stiffness and
(d) provided relief from OA
symptoms for up to 3 months after stopping treatment
Not all studies are positive, however, and several
more recent ones have not found any positive effect from taking glucosamine For
example, in the large clinical trial by Sawitzke et al. (2008), called the 2006
Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT), conflicting and
somewhat confusing results. The study of about 1,600 people with OA of the knee
found that glucosamine alone, or in combination with chondroitin did not reduce
pain in the overall group, although it did appear to lessen pain among those
with moderate to severe OA of the knee. This study has provided the impetus for
further research. Studies are currently being conducted to see whether the
glucosamine-chondroitin combination may in fact help those with more severe OA
in an attempt to see whether any benefit is seen in more severe cases. The study also tested whether glucosamine or
chondroitin (together or alone) slowed the loss of cartilage in their knees.
They showed no difference in cartilage loss compared with people who took
placebo. In light of these conflicting findings, more research is warranted on
Glucosamine before it can conclusively be said to be effective.
References
Glucosamine products pictured in this article are trademarks of NOW and Solgar.
Buckwalter, JA. 2003.
Sports, joint injury, and posttraumatic osteoarthritis. Journal of Orthopaedic
and Sports Physical Therapy, 33: 578–588.
Fallon K. Glucosamine in
the management of osteoarthritis. Int SportsMed J. 2001; 2(4).
Ostojica S.M, M. Arsicb,
S. Prodanovicc, J. Vukovica & M. Zlatanovicd. Glucosamine Administration in
Athletes: Effects on Recovery of Acute Knee Injury. Research in Sports
Medicine: An International Journal. Volume 15, Issue 2, 2007. pages 113-124
Sawitzke et al. The Effect
of Glucosamine and/or Chondroitin Sulfate on the Progression of Knee
Osteoarthritis: A GAIT Report. Arthritis Rheum. 2008 October; 58(10): 3183–3191
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Glucosamine products pictured in this article are trademarks of NOW and Solgar.
ReplyDeleteIts like you read my mind! You appear to know a lot about this, like you wrote the book in it or something.
I think that you could do with some pics to drive the message home a bit, but instead of that, this is great blog.
An excellent read. I’ll certainly be back.
natural pain supplement
Thanks Khuram. I appreciate it. Indeed, I did a great deal of research on supplements. Stay tuned!
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